LINE 1: “PRECLINICAL STUDIES”

Coordinator: Dr Fabrizio Ensoli

This LINE concerning four Macro-Areas:

  • Microbiome and Skin
  • Cellular Interactions in Inflammatory Pathologies
  • Cellular Interactions in Neoplastic Pathologies
  • Cellular Interactions in Regenerative Medicine.

The skin is responsible for homeostasis between the external and internal environments and represents a valuable model of study on the mechanisms of response to environmental stimuli, including the relationship between host and microbiome, and on the development of inflammatory and neoplastic processes. The creation of in vitro models on the interaction between microbiome and skin and the analysis of the biochemical alterations underlying the pathological processes are necessary for the definition of the pathogenetic mechanisms and the identification of specific therapeutic targets. In particular, the definition of adequate models for the study of the interactions between resident cells and skin transients is fundamental to explore and identify the mechanisms of onset of inflammatory, degenerative or neoplastic diseases and helps to offer the basis for the evaluation of regeneration mechanisms. Finally it represents an essential prerequisite for the identification of appropriate therapeutic targets.

GOALS:

  • Microbiome analysis in inflammatory skin diseases such as atopic dermatitis, acne and psoriasis.
  • Microbiome analysis in difficult wounds.
  • Development of new tests for the characterization of the microbial biofilm and evaluation of pathogenetic mechanisms induced by microbial strains producing biofilm.
  • Control mechanisms of keratinocyte proliferation and differentiation.
  • Study of the cross-talk between cell populations in inflammatory and degenerative skin processes.
  • Analysis of the intra- and extracellular microenvironment in the pathogenesis and development of cutaneous neoplasms.
  • Impact of growth factors and cellular interactions in tissue regenerative processes (regenerative medicine).