Clinical research on new minimally invasive surgical techniques, imaging advances in early cancer detection or imaging-guided surgery and oncologic outcomes after surgical treatments are our main research objectives. Translational research on molecular biomarkers, genetic and microenvironment tumor profiling, stem cells investigation, together with new precision medicine diagnostic and prognostic not invasive tools in urological malignancies as liquid biopsy or E-nose volatilome profiling are additional research activities that our Unit carries out in cooperation with dedicated departments of the Regina Elena National Cancer Institute and other prestigious national and international Institutions. The Urology Unit has been national site coordinator of observational studies and it is involved in multiple clinical trials on prostate cancer treatments, renal cancer and urothelial cancer.